Therapeutic effect and safety of nateglinide combined with insulin glargine in treatment of aged patients with type 2 diabetes

OBJECTIVE To evaluate the comparison of efficacy and safety between nateglinide combined with insulin glargine and mixed protamine zinc recombinant human insulin in treatment of aged patients with type 2 diabetes.METHODS Fourty aged patients with type 2 diabetes under unsatisfied blood glucose control were randomly divided into 2 groups.20 patients in the trial group were treated by nateglinide with insulin glargine injection.The other 20 patients in the control group were treated by mixed protamine zinc recombinant human insulin injection.Fasting blood glucose(FBG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)and hypoglycemia before and after the treatment were observed in two groups.RESULTS The levels of FBG,2hPG and HbA1c in trial and control groups after treatment showing significant difference in comparison with those before treatment.But no significant difference between the two groups(P0.05).Hypoglycemia in trial group appeared more frequently than in control group.(P0.01).CONCLUSION Insulin glargine with Nateglinide can control the blood glucose effectively in aged patients with type 2 diabetes possessing low incidence of hypoglycemia and high safety accompanied by simple and easy way in application.