The significance of NSE and S-100β protein levels in CSF and serum of children with EV71 encephalitis

Objective To study the early diagnostic significance of neuron-specific enolase ( NSE ) and S-100β protein in diagnosing EV71 encephalitis by detecting the level of NSE and S-100β protein in cerebrospinal fluid and serum in children infected with EV71. Methods Totally 100 patients with EV71 encephalitis hospitalized in our hospital from May 2008 to December 2010 were chosen to be the study group,and 89 patients with other viral encephalitis and 22 pa tients without encephalitis hospitalized in our hospital in the same period were chosen to be the control group. The con centration of NSE and S-100β protein in cerebrospinal fluid and serum were detected by ELISA technique. Results The concentration of NSE in cerebrospinal fluid,from patients in EV71 type encephalitis acute stage,was lower than oth er types of virus encephalitis group (P 0.05 ) .In acute stage,the concentrations of NSE and S100β protein in cerebrospi nal fluid and serum from patients with EV71 type encephalitis were obviously higher than EV71 ordinary type encephali tis (P 0.05 ), and in convalescence stage,the concentrations were also higher than ordinary type (P 0.01 ) . Conclusion The concentrations of NSE and S-100β protein in cerebrospinal fluid and serum could be used to earlier evaluate the degree of injury and prognosis of intracranial infection in EV71 type encephalitis.