Relationship between neuron-specific enolase levels in serum or cerebrospinal fluid andclinic in patients with epidemic encephalitis B

Objective To analyze the relationship between neuron-specific enolase(NSE) levels and extents of cerebral injury in patients with epidemic encephalitis B, and to study the use of NSE in the pathogenetic of epidemic encephalitis B. Method The NSE contents were measured by double antibody sandwich assay. Results NSE contents in serum and cerebrospinal fluid (CSF) in patients with epidemic encephalitis B rised in the primary phase, reached the maximum in the crisis phase, and falled in the recovery phase. The difference of NSE contents in the primary phase compared with it in the crisis phase in serum and CSF in all types of patients had notable statistic significance(P0.01), and the difference of NSE contents in the recovery phase had statistic significance(P0.05). Conclusion It is helpful for the judgement of patients′ condition with epidemic encephalitis B to measure the NSE contents.