Effect of Dexmedetomidine on Clinical Profiles in Patients with Hypertension in the Period of Tracheal Extubation

Objective:To determine the effect of administration of dexmedetomidine by the end of operation on clinical profiles in the period of extubation in general anesthesia patients with hypertension.Methods: 40 patients with hypertension who were undergoing lower abdominal or pelvic surgery were randomly divided into control group(group C) or dexmedetomidine group(group D).The scheme of induction and maintenance of anesthesia of the two groups were identical.Patients in group D were administered dexmedetomidine at a dose of 1ug/kg over 10 min and in group C patients were given a placebo infusion of normal saline at identical rates at 30 min by the end of the operation.Systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),pulse oxygen saturation(SpO2),the recovery time(open eye,t1),extubation time(t2) and adverse effects were recorded.Results:SBP、DBP、HR in group D during peri-extubation were significantly different from those in group C which fluctuated more markedly(p0.05).Tolerance score to endotracheal tube in group D was superior to that in group C(p0.05).Conclusion: Dexmedetomidine could effectively reduce the cardiovascular response to extubation in patients with hypertention and strengthen the patients' tolerance to endotracheal tube.