Effects of Loading-dose Atorvastatin on Apoptosis,Myocardial Damage and Major Adverse Cardiac Events in Acute Coronary Syndrome Patients Undergoing Selected Percutaneous Coronary Intervention

【Objective】 To investigate the effects of loading-dose atorvastatin on apoptosis,myocardial damage and major adverse cardiac events(MACE) in patients with acute coronary syndrome undergoing selected percutaneous coronary intervention(PCI).【Methods】 A total of eighty-five acute coronary syndrome patients undergoing selected PCI were randomized to study group(n = 42) and control group(n = 43).All patients were given atorvastatin 20 mg/d,while study group received loading-dose atorvastatin 80 mg before 8 hours of PCI.Fas,which is involved in the physiopathological process of apoptosis,was measured before PCI,6 hours and 24 hours after PCI.Troponin T(cTnT) was measured before PCI and 24 hours after PCI.MACE in 3 months after PCI was recorded.【Results】 In study group,The Fas levels before PCI as well as 6 hours and 24 hours after PCI were decreased sequentially,but the differences were not statistically significant.In control group,the Fas level measured 24 hours after PCI had an increasing tendency as compared with that measured 6 hours after PCI(P = 0.056).Compared between study group and control group,the Fas levels both in study group and control group measured before PCI and 6 hours after PCI were similar;The Fas level in study group was lower than that in control group 24 hours after PCI(P = 0.013).The cTnT level was decreased measured 24 hours after PCI in study group(P 0.001),but not changed in control group.The cTnT level measured 24 hours after PCI was significantly lower in study group than that in control group(P = 0.03).The MACE in 3 months after PCI in study group was less than that in control group.【Conclusion】 This study demonstrated that selected PCI could induce the increase of Fas level after PCI in patients with acute coronary syndrome.And loading-dose atorvastatin used before 8 hours of PCI could decrease the levels of Fas as well as cTnT measured 24 hours after PCI,also reduce the occurrence of MACE in 3 months after PCI.