Effects of atorvastatin loading on recent cardiovascular events in patients with unstable angina after percutaneous coronary intervention

Objectives To observe the effects of atorvastatin loading on recent myocardial injury,myocardial perfusion and cardiovascular events in patients with unstable angina(UA) after percutaneous coronary intervention(PCI).Methods Totally 56 patients with UA undergoing PCI in Wuyi Traditional Chinese Medicine Hospital of Jiangmen from November 2009 to October 2011 were randomly divided into treatment group(n =28) and control group(n =28).Treatment group were given a 40 mg/d loading dose of atorvastatin in seven days preoperative.After PCI,two groups were both given atorvastatin 10 mg/d.Levels of serum MB isoenzyme of creatine kinase(CK-MB),troponin I(TnI) and nitric oxide(NO) were measured before PCI,24 h and 3 d after PCI.TMI myocardial perfusion(TMP) was assessed before PCI and immediately postoperatively.Major adverse cardiovascular events(MACE) were recorded in 3 months after PCI.Results CK-MB and TnI levels improved significantly 24 h after PCI,declined 3 d after PCI in the two groups;levels of CK-MB and TnI in treatment group were significantly lower than those in control group(P= 0.037,P=0.046).NO levels of the two groups improved significantly after operation,and treatment group increased more significantly(P =0.049).Incidence of TMP 0/1 level in treatment group was significantly lower than that in control group before and after PCI(P =0.017,P =0.019).After 3 months’ follow-up,MACE of treatment group was 10.7% and was significantly lower than that of control group(21.4%).Severity of cardiovascular disease in treatment group was significantly lighter than that in control group(P0.05).Conclusions Atorvastatin loading given before PCI can improve UA patients’ postoperative myocardial perfusion,reduce myocardial injury,reduce the incidence of MACE in 3 months after surgery and the severity of disease,thus lead to improvement of patients’ prognosis.