Effects and mechanisms of loading dosage of atorvastatin in reducing periprocedural cardiovascular events in patients undergoing percutaneous coronary intervention

Objective To evaluate the mechanisms of loading dosage of atorvastatin in reducing cardiovascular events in patients undergoing percutaneous coronary intervention(PCI).Methods Fifty-eight patients who had been diagnosed with coronary heart disease(CHD) and would receive PCI were randomized to loading dosage group(n=30) and routine group(n=28).All patients received atorvastatin treatment at least 30 days thereafter(40 mg/day).The levels of serum Lp-PLA2,hs-CRP,Aminotransferase(ALT) and Creatine kinase(CK) at different time(before PCI,24 hours after PCI and 10 days after PCI) were tested.30-day incidence of major adverse cardiac events was done in a follow-up.Results ① The levels of serum Lp-PLA2 and hs-CRP in two groups decreased dramatically 10 days after PCI.There were significant differences when PCI 10 d to PCI 24 h and pre-PCI were compared(P0.01).② The hs-CRP in loading group decreased dramatically after PCI 24 h,which was statistically different(P=0.02) between the two groups,but the Lp-PLA2 decreased lightly and there was no difference(P0.05) between two ones after PCI 24 h.There were no statistical differences at different time(before PCI and 10 days after PCI) of the two inflammation factors(P0.05) between two groups.③ The incidence of ardiovascular events in loading group decreased 21.7% than routine group(P0.05) and the ALT and CK showed no statistical differences before and after PCI(P0.05) in loading group.Conclusion Loading dosage of atorvastatin depresses inflammation activity stronger and would reduce cardiovascular events further during CHD periprocedural period and loading dosage of atorvastatin is credible and believable.