Clinical Study on Preventing of Postpartum Bleeding in Term Pregnancy by Misoprostol

objective:To observe the efficacy of misopristol on preventing postpartum bleeding. Methods:Two hundred and sixty-two puerperant patients in term pregnancy were randomized into three groups: misoprostol group (n = 85), 400 u,g misoprostol was given orally immediately after parturition; misoprostol plus oxytocin group ( n = 90), 400 pig misoprostol was given orally and 10 IU oxytocin was injected into muscle and 10 IU intravenously administrated immediately after parturition; oxytocin group ( n = 87), 10 IU oxytocin was injected into muscle and 10 IU intravenously administrated immediately after parturition. The amount of bleeding of 2 hours just after parturition, the rate of puerperant bleeding, the duration of third stage of labour and blood pressare were recorded in above three groups. Results: The mean amount of bleeding, the rate of postpartum hemorrhage and the duration of third stage of labor in misoprostol group were (221 +55)ml, 2. 35% and (6. 2 +3. 0)minutes, in misoprostol proup were (214 +49)ml, 2. 22% and (5. 8 +3. 3) minutes, and in oxytocin group were(278+56) ml, 14.94% and (8. 7 +4.0) minutes, respectively. There were significant differences between misoprostol group and oxytocin group ( P 0. 01 or P 0. 05), there were no differences between misoprostol group and misoprostol plus oxytocin group. Conclusion: Misoprostol is more effective on preventing puerperant bleeding than oxytocin.