Influence of Resveratrol on Cell Apoptosis of Lewis Lung Carcinomas

Objective To explore the influence of resveratrol(Res) on apoptosis of Lewis lung carcinoma in mice.Methods The Lewis lung carcinoma models of C57BL mice were established.Forty C57BL mice were randomly divided into 4 groups: control group,low-dose Res group(2.5 mg/kg·d),middle-dose Res group(5 mg/kg·d) and high-dose Res group(10mg/kg·d).There are 10 mice in every group.Different treatments were served from day 2 after transplantation and all mice were sacrificed after 22 days.The volume and weight of tumors were detected.Apoptosis index(AI) was determined by TUNEL assay. Results The tumor growth was suppressed significantly in middle-dose and high-dose Res group.The weight and volume of tumor were markedly decreased in those groups compared with control group(P0.01) and their inhibitory rates were 39.41%and 50.35% respectively,which was higher than low-dose Res group(11.81%)(P0.01).AI was enhanced in middle-dose and high-dose group compared with control group(P0.01).However,low-dose Res had no obvious influence on AI(P0.05). Conclusion Resveratrol can remarkably inhibit Lewis lung carcinoma growth in mice.Its mechanism might be associated with promoting apoptosis.