EFFECTS OF TEA POLYPHENOL ON GROWTH INHIBITION,ANTI-METASTASIS AND INDUCTION OF APOPTOSIS OF LEWIS LUNG CANCER IN MICE

Objective To study the effects of tea polyphenol(TP) on inhibition of tumor growth and metastasis as well as induction of apoptosis in tumor bearing mice. Methods C57BL/6J mice implanted with Lewis lung cancer were administered with TP, 62.5 mg/kg,125.0 mg/kg,250.0 mg/kg daily, respectively, through a gastric tube for 13 days, while normal saline for the control. Results At dose of 62.5 mg/kg, TP showed no inhibition on the cancer cells. With the dose of 125.0 mg/kg and 250.0 mg/kg , tumour inhibition was 27.2% and 18.8%, respectively. In control group, apoptosis index was 24.90±2.42; apoptosis indexes of TP at doses of 62.5 mg/kg,125.0 mg/kg,250.0 mg/kg were 23.90±2.81,43.00±2.58 and 33.38±2.13, respectively. There were great differences among the control group,125.0 mg/kg group and 250.0 mg/kg group( F=123.56,q= 10.044 ,22.740,P 0.001).The average number of metastatic foci on lung surface decreased from 13.17 to 5.17 by taking TP for three weeks ( t=7.14,P0.01 ). Conclusion TP can inhibit the growth and metastasis of Lewis lung cancer, the underlying mechanism of which is associated with induction of apoptosis.