ScholarLens Back to search
2013•Northwest Pharmaceutical JournalRequires access

The proliferation and apoptosis effects of polyphenols of pomegranate peel on hu-man prostate cancer PC-3 cells

Xiaoran Wang

Open publisher page 0 citations

Abstract

Objective To study the anticancer activity and apoptosis effects of polyphenols of pomegranate peel on human prostate cancer PC-3cells.Methods Methyl thiazolyl tetrazolium(MTT)assay was used to detect the proliferation of PC-3cells.The cell apoptosis and changes of cell cycle of PC-3cells were analyzed by using flow cytometry after treated with 72h.Results Polyphenols of pomegranate peel significantly inhibited the cell proliferation of PC-3cells in dose and time dependent manners.The results of flow cytometry showed that polyphenol of pomegranate peel can arrest the cells in cycle progression at G1phase,and obviously induce the apoptosis of PC-3cells.Conclusion Polyphenols of pomegranate peel could inhibit the proliferation and apoptosis of PC3cells.

About this research paper

What this paper is about

Objective To study the anticancer activity and apoptosis effects of polyphenols of pomegranate peel on human prostate cancer PC-3cells.Methods Methyl thiazolyl tetrazolium(MTT)assay was used to detect the proliferation of PC-3cells.The cell apoptosis and changes of cell cycle of PC-3cells were analyzed by using flow cytometry after treated with 72h.Results Polyphenols of pomegranate peel significantly inhibited the cell proliferation of PC-3cells in dose and time dependent manners.The results of flow cytometry showed that polyphenol of pomegranate peel can arrest the cells in cycle progression at G1phase,and obviously induce the apoptosis of PC-3cells.Conclusion Polyphenols of pomegranate peel could inhibit the proliferation and apoptosis of PC3cells.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the anticancer activity and apoptosis effects of polyphenols of pomegranate peel on human prostate cancer PC-3cells.Methods Methyl thiazolyl tetrazolium(MTT)assay was used to detect the proliferation of PC-3cells.The cell apoptosis and changes of cell cycle of PC-3cells were analyzed by using flow cytometry after treated with 72h.Results Polyphenols of pomegranate peel significantly inhibited the cell proliferation of PC-3cells in dose and time dependent manners.The results of flow cytometry showed that polyphenol of pomegranate peel can arrest the cells in cycle progression at G1phase,and obviously induce the apoptosis of PC-3cells.Conclusion Polyphenols of pomegranate peel could inhibit the proliferation and apoptosis of PC3cells.

Key concepts: Polyphenol, Apoptosis, Flow cytometry, Cell cycle, Chemistry, Cell growth, Cell, MTT assay

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The proliferation and apoptosis effects of polyphenols of pomegranate peel on hu-man prostate cancer PC-3 cells — Research Paper | ScholarLens