The relationship between serum adiponectin levels and Insulin resistance in metabolic syndrome patients Without diabetes

Objective To investigate serum adiponectin levels in metabolic syndrome patients without diabetes and to analyse the relationship between serum adiponectin levels,and Insulin resistance(IR).Methods 92 metabolic syndrome patients without diabetes and 30 health persons were investigated. Serum adiponectin levels of all subjects were determined by using enzyme linked immunosorbent assay(ELISA).Homeostasis insulin resistance index (Homa-IR) and insulin sensitivity index(ISI) were calculated.And then,the relationship between serum adiponectin levels and Insulin resistance(IR) wil be analysed.Results 1.The serum level of adiponectin was significantly lower in metabolic syndrome without diabetes group than in normal control group (1.15±0.81mg/l,4.81±1.20 mg/1,P0.01 =).2.The serum adiponectin level was negatively correlated with Homa-IR(P0.01).and positively correlated with ISI through linear correlation analysis(P0.01).However,the serum adiponectin level was only negatively correlated with Homa-IR through multiple linear regression analysis.Conclusions The level of serum adiponectin in metabolic syndrome cases without diabetes was significantly decreased.The serum adiponectin level was negatively correlated with Homa-IR.This shows that level of serum adiponectin was correlated with metabolic syndrome and insulin resistance.