The Follow-Up Research of the Relationship between Hyperhomocysteinemia and Vascular Event Recurrence Rate after a Previous Stroke

Objective:To explore the possible effect of the plasma homocysteine(Hcy) level on the risk of recurrent vascular events including ischemic stroke,transient ischemic attach(TIA),angina,myocardial infarction and peripheral arterial disease by follow-up research in hope for finding a new theoretical evidence for the therapy and the prophylaxis of vascular diseases.Methods:The plasma Hcy was determined by high-performance liquid chromatography in 151 patients with acute cerebral infarction and 52 age-and gender-matched healthy controls.The patients were divided into hyperhomocysteinemia(Hhcy) group and no hyperhomocysteinemia(Nhhcy) group according the outcome.Within a 5-years follow-up period,the recurrence of vascular events was observed in the 2 groups.Results:There was no statistical difference in common information between Hhcy and Nhhcy groups.But the recurrence rate of the Hhcy group,being 50.82%,was significantly higher than that of 24.44% in Nhhcy group(P 0.01).By forward stepwise logistic analysis,the increased Hcy was found that was an independent risk factor of the recurrent vascular events(P 0.01;OR=1.182;95%CI:1.112-1.257).Conclusion:Hhcy is closely correlated with the recurrent vascular events after a previous ischemic stroke.