The follow-up research on the relationship between hyperhomocysteinemia and the prognosis of patients with transient ischemic attacks of internal carotid artery system

Objective To explore the possible effect of the plasma homocysteine level on the risk of recurrent ischemic cerebral vascular events by following up in transient ischemic attacks(TIA) patients in hope for finding new theoretical evidence for the therapy and the prognosis evaluation of TIA.Methods The free plasma homocysteine(Hcy) of 119 patients with internal carotid artery system TIA and 52 age-and gender-matched healthy controls were determined by high-performance liquid chromatography,then the patients were divided into hyperhomocysteinemia(Hhcy) group and no hyperhomocysteinemia(Nhhcy) group according to the result.Within a two-year followup period,the recurrence of ischemic cerebral vascular events were observed.Results There was no statistical deference in common information between Hhcy and Nhhcy group.But the recurrence rate of the Hhcy group(64.58%) was significantly higher than 43.66% of Nhhcy group(P0.05).By forward stepwise Logistic analysis,we found that Hhcy was a independent risk factor for the recurrent ischemic cerebral vascular events(P0.01;OR=3.975;95%CI:1.548~10.206),as hypertension,diabetess mellitus and hypercholesteremia.Conclusions Hhcy may be correlated with the recurrent ischemic cerebral vascular events after previous TIA.