The expression of P16 and P53 protein and their significance in breast carcinoma

Objective To study the expression of P16 and P53 protein and discuss their relationship and clinical significance in breast carcinoma. Methods The expression of P16 and P53 protein were detected in 76 cases of breast carcinoma with immunohistochemical S-P technique. Results P16 protein was localized in nuclear and/or cytoplasm of breast carcinoma, and the expression of P16 protein was associated with clinical stage and lymph node metastasis( P 0.05), but no association with age, tumor size, histological grade, histological type. P53 was expressed in tumor nuclear and it was correlated with histological grade and lymph node metastasis( P 0.05), but there was no relationship with other clinical pathological factors. There was no significant correlation between the expression of P16 and P53 protein. Conclusion The loss of P16 protein and over-expression of P53 protein are related to the genesis and development of breast carcinoma, P16 and P53 protein may be referred indication to determine biological behavior and prognosis of breast carcinoma.