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2006•Chinese Journal of MisdiagnosticsRequires access

Significance of Maspin Protein Expression in Breast Cancer

Xing Lu-qi

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Abstract

Objective:To explore the character and significance of Maspin expression in different breast cancer.Methods:Maxvision immunohistochemical method was used to assess the expression of Maspin in different breast carcinoma.And the relationship between expression of Maspin and that of ER,PR,C-erbB-2,VEGF,MVD,lymph node metastasis in invasion lobular carcinoma,ductal carcinoma was statistically analyzed.Results:Positive expression in ductal carcinoma in stiu,invasive carcinoma of no special type,infiltrating lobular carcinoma was 36.4%,23.5%,9.1% respectively,but no significant statistical difference(P0.05) between groups.Maspin expression was not found in Medullary carcinoma and tubular carcinoma.Maspinpositive cases showed a significant decrease in MVD and/or C-erbB-2 expression(P0.05).Conclusions:Maspin may depend largely on its antiogentic activity to inhibit tumor.

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Objective:To explore the character and significance of Maspin expression in different breast cancer.Methods:Maxvision immunohistochemical method was used to assess the expression of Maspin in different breast carcinoma.And the relationship between expression of Maspin and that of ER,PR,C-erbB-2,VEGF,MVD,lymph node metastasis in invasion lobular carcinoma,ductal carcinoma was statistically analyzed.Results:Positive expression in ductal carcinoma in stiu,invasive carcinoma of no special type,infiltrating lobular carcinoma was 36.4%,23.5%,9.1% respectively,but no significant statistical difference(P0.05) between groups.Maspin expression was not found in Medullary carcinoma and tubular carcinoma.Maspinpositive cases showed a significant decrease in MVD and/or C-erbB-2 expression(P0.05).Conclusions:Maspin may depend largely on its antiogentic activity to inhibit tumor.

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Available abstract

Objective:To explore the character and significance of Maspin expression in different breast cancer.Methods:Maxvision immunohistochemical method was used to assess the expression of Maspin in different breast carcinoma.And the relationship between expression of Maspin and that of ER,PR,C-erbB-2,VEGF,MVD,lymph node metastasis in invasion lobular carcinoma,ductal carcinoma was statistically analyzed.Results:Positive expression in ductal carcinoma in stiu,invasive carcinoma of no special type,infiltrating lobular carcinoma was 36.4%,23.5%,9.1% respectively,but no significant statistical difference(P0.05) between groups.Maspin expression was not found in Medullary carcinoma and tubular carcinoma.Maspinpositive cases showed a significant decrease in MVD and/or C-erbB-2 expression(P0.05).Conclusions:Maspin may depend largely on its antiogentic activity to inhibit tumor.

Key concepts: Maspin, Medicine, Immunohistochemistry, Breast cancer, Carcinoma, Breast carcinoma, Lobular carcinoma, Invasive lobular carcinoma

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