2007•Suzhou Daxue xuebao. Yixue banRequires access
The Clinical Significance of Maspin Expression in Breast Cancer
Feng Li
Open publisher page 1 citations
Abstract
Objective To explore the significance of Maspin expression in invasive breast cancer.Methods Envision immunohistochemical method was used to assess the expression of Maspin in 82 cases of invasive breast cancer,16 breast cancer in situ,20 cases of ductal epithelial simple hyperplasia and 15 normal tissues.The clinical pathological significance of Maspin expression was evaluated.Results The expression of Maspin in normal tissues,simple ductal epithelial hyperplasia,breast cancer in situ and invasive breast cancer was 100%,90%,75%,45.1% respectively,which were all lower than that in the controls(P0.05).The result of analysis showed that the expression of Maspin in invasive breast cancer was negatively correlated with the TNM grading and lymph node metastasis.Meanwhile the expression of Maspin related survivals(P0.05).Conclusion The Maspin protein maybe act an important role in the development of breast cancer.The expression of Maspin was closely relates to the survival rate and can be used as the predictor of prognosis.