Expression of Vascular Endothelial Growth Factor and Maspin in Breast Carcinoma and its Clinical Significance

Objective: To explore the expression of VEGF and Maspin protein in breast cancer tissues.Methods: We examined the expression of the level of VEGF and Maspin expression in breast cancer tissues and adjacent breast normal tissues by immunohistochemistry.Results:The expression rate of VEGF was 91.1%(82/90)in breast carcinoma tissues,but 44.4%(40/90)in normal tissues;as for Maspin,the case was to contrary,the expression rate of Maspin protein was 68.9%(62/90)in breast carcinoma tissues,and 100%(90/90)in normal tissues.There was correlation between the expression of these two proteins.The expression of VEGF was related to TNM stage and lymph node metastasis of breast carcinoma(P0.01),there was a close relation between the expression of Maspin and histology type,histology grade and lymph node metastasis of breast carcinoma(P0.05).Conclusion:These results demonstrate that examination of expression of VEGF and Maspin at the same time might be beneficial in judging biological behavior and prognosis of breast carcinoma.