Research on clinical value of serum cystatin C,beta 2 microglobulin and traditional markers in different stages of renal function impairment

Objective To evaluate the clinical application value of serum cystatin C(serum CysC),β2microglobulin(β2MG) and other traditional markers such as creatinine( Cr),urea nitrogen( BUN) and uric acid( UAc) in different stages of renal function impairment,especially in the early impairment of renal function. Methods One hundred outpatients and hospitalized patients in different courses of renal function impairement,and 100 healthy subjects as control group were selected to detect the serum CysC,β2MG,Cr,BUN and UAc by full- automatic biochemical analyzer. Results Serum CysC and β2MG showed significant difference between control group and patient group(P 0. 01),while the difference of serum Cr,BUN and UAc had no statistical significance between the patients in early stage of renal impairment without clinical symptoms and control group(P 0. 05). The combined detection of serum CysC and β2MG exhibited higher positive rate compared with the single detection,up to 92. 3%. Conclusion Serum CysC and β2MG are more sensitive and accurate to reflect the glomerular filtration rate(GFR) than serum Cr,BUN,UAc. Combined detection of serum CysC and β2MG has important clinical value in diagnosis of early renal damage.