Effect of trimetazidine in patients with unstable angina pectoris

Objecticve To evaluate the effect of trimetazidine in patients with unstable angina pectoris on conventional therapy.Methods One hundred and three patients with unstable angina pectoris,who were randomized into conventional therapy group (51 patitents) and trimetazidine therapy group (52 patients),were involved in this study.In the conventional therapy group,patients accepted the treatment with nitrate,calcium antagonist,angiotensin-converting enzyme inhibitor,β-blocker and aspirin.In the trimetazidine group,trimetazidine (20 mg,3 times daily) were given in addition to conventional therapy.The treatment durations in both groups were (28±2) days.The symptoms,heart rate,blood pressure,ambulatory 24-hour electrocardiography and side effects were observed.Results Compared with the conventional therapy group,in the trimetazidine group, the treatment efficacy was better (P 0.01); trimetazidine had no effect on heart rate,blood pressure and rate pressure production; the reduction of the number of ischemic episodes,maximal ST-segment depression and the total time of ischemic episodes were more significant (all P 0.01).Conclusions Combination therapy of trimetazidine and conventional drugs releases unstable angina pectoris more effectively,reduces the number of ischemic episodes,maximal ST-segment depression and the total time of ischemic episodes more significantly.There is no effect on circulation kinetics.Its side effects are light.It is a safe,effective and more perfect therapic protocol to unstable angina pectoris.