The Clinical Therapeutic Effects of Trimetazidine Combined with Usual Therapy for Unstability Angina Pectoris

Objective:To evaluate the clinical therapeutic effects of trimetazidine combined with usual therapy for unstability angina pectoris.Methods: 86 patients with unstable angina pectoris were randomized into routine treatment group and combined treatment group.In the routine treatment group patients accepted the treatment with nitrate,calcium antagonist,angiotensin-converting enzyme inhibitor,β-blocker and aspirin.In the combined treatment group trimetazidine(20mg,3 times daily) was given in addition to routine therapy.The treatment durations in both groups were 12 weeks.The symptoms,heart rate,blood pressure,ambulatory 24-hour electrocardiography and side effects were observed.Results: The treatment efficacy of the trimetazidine group was better than that of the routine treatment group(P0.01),the reductions of the number of ischemic episodes,maximal ST-segment depression and the total time of ischemic episodel were more significant(P0.01).Conclusions: Combination therapy of trimetazidine and conventional drugs releases unstable angina pectoris more effectively.Trimetazidine can improve the unstability angina pectoris in patients.So it is valuable to be spread broadly in clinic.