Comparison study of clinical characteristics between depression and depression comorbid with diabetes mellitus

Objective: To explore clinical characteristics and curative effect between depression and depression comorbid with diabetes mellitus. Method:Patients with depression comorbid either with (n=40) or without (n=40) diabetes mellitus were enrolled in this study.Hamilton depression scale (HAMD),Hamilton anxiety scale (HAMA) and the social disability screening schedule(SDSS) were used to evaluate the clinical characteristics and social functions at baseline and after 12 weeks treatment by SSRIs. Results:The patients with diabetes mellitus had higher total scores in HAMD,HAMA and SDSS at baseline and 12 weeks later (P0.05),and higher scores on anxiety/somatization,cognitive,hopelessness and retardation of HAMD at baseline (P0.05).The patients with diabetes mellitus showed less reduction rates than the patients without diabetes mellitus through 12 weeks treatment (P0.05). Conclusion:The patients with major depressive disorder and diabetes mellitus had more severe symptoms and social function impairment,and less curative effect.