Changes of serum level of interleukin-6 and interleukin-10 after coronary stent implanation

Objective To investigate the changes of the serum level of IL-6 and IL-10 as well as their significance after coronary artery stent implantation. Methods The study involved 30 patients who underwent coronary artery stent implantation. Blood stamples were taken from the femoral arteries before and 24h after successful coronary stenting. Serum concentration of interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured and complications as well as the occurance of restenosis were observed after the procedure. Results The concentration of IL-6 in femoral aterial blood was significantly higher after 24 hours of stent-implantation (214.6±118.0 ng/L vs 175.8±81.8 ng/L, P 0.05). IL-10 level was slightly decreased after 24 h, P 0.05, and the ratio of IL-6/IL-10 increased (3.2±1.9 vs 2.3±1.0, P 0.05). In patients with restenosis the concentration of IL-6 raised more tramandously (302.0±156.8 ng/L vs 192.7±98.6 ng/L, P 0.05) and the ratio of IL-6/IL-10 is much righer (5.4±2.0 vs 2.7±1.5, P 0.01) than patients without restenosis. Conclusion Stent-implantation induces increase in serum concentration of IL-6 and the IL-6/IL-10 ratio. The increase of serum IL-6 and the IL-6/IL-10 ratio may play an important role in the incidence of complication and restenosis after coronary stent implantation.