Changes of serum interleukin-6 and interleukin-10 after coronary stent implantation

AIM: To investigate the changes of pro-inflammatory cytokines interleukin-6(IL-6) and anti-inflammatory cytokines interleukin-10(IL-10) in the peripheral circulation after coronary stent implantation.METHODS: The study involved 30 patients who underwent coronary artery stent implantation.Blood samples were taken from the femoral arterial blood before and 24 h after coronary stenting.Serum levels of interleukin 6(IL-6) and interleukin 10(IL-10) were measured and complications were(observed).RESULTS: The level of IL-6 in femoral arterial blood was significantly increased 24 h after implantation(215±118 pg/ml vs 176±82 pg/ml,P0.05),while IL-10 level was slightly decreased with no significant difference.IL-6/IL10 ratio was markedly increased(3.3±1.9 vs 2.3±1.0,P(0.01)).In patients with restenosis or cardiovascular complications,IL-6 level(302±157pg/ml vs 193±99 pg/ml,P0.05) and the ratio of IL-6/IL-10(5.4±2.0 vs 2.7±1.5,P0.05) were significantly higher than in those without these conditions.CONCLUSION: Stent-implantation-induced elevation of IL-6 and IL-6/IL-10 ratio may contribute to the complications and restenosis after coronary stent(implantation).