Comparison of different combinations of ondansetron,metoclopramide and dexamethasone in prevention of postoperative nausea and vomiting in patients undergoing oralmaxiilofacial surgery

Objective To compare the efficacies of different combinations of ondansetron,metoclopramide and dexamethasone in prevention of postoperative nausea and vomiting(PONV)in patients undergoing oral and maxillofacial surgery.Methods Nine hundreds and seventy sevenⅠ-Ⅱpatients(American Society of Anesthesiologists[ASA])undergoing oral and maxillofacial surgery,aged from 20 to 75 years old,were inclu- ded in the present study.All patients received general anesthesia and patient-controlled intravenous analgesia (PCIA).Antiemetic formula were randomly divided into 3 groups.Group A..metoclopramide 30 mg;group B: ondansetron 4 mg+metoclopramide 30 mg;group C:ondansetron 4 mg+dexamethasone 5 mg+metoclo- pramide 30 mg.Results The incidences of PONV in group C(1.1%)was significantly lower than those of group A(41.9%)and B(18.8%),and that of group B was significantly lower than that of group A(P0.05).The rate of severe vomiting was 63.60% in group A,31.0% in group I3 and none in group C.Conclusion Ondansetron combined with dexamethasone or metroiopramide has strong antiemetic effect in treatment of PONV.