Observation of pre-emptive analgesic effects of Parecoxib Sodium in upper limb fractures

Objective To observe the pre-emptive analgesic effects of Parecoxib Sodium in upper limb fractures.Methods Sixty patients with upper limb fracture(ASA level Ⅰ-Ⅱ) were randomly divided into group A(Parecoxib Sodium group),group B(Fentanyl group) and group C(control group).Group A and group B received the intravenous injection of 40 mg of Parecoxib Sodium and 1 μg/kg of Fentanyl respectively.Group C received routine interscalene brachial plexus block 10 minutes later instead of any drug.The patients' MAP and HR at T0(when entering the operating room),T1(10 minutes after anesthesia),T2(at skin incision) and T3(30 th minute of surgery) were observed.Patients' degrees of pain at rest and activity at T4(2 hours after surgery),T5(4 hours after surgery) T6(8 hours after surgery) and T7(12 hours after surgery) were evaluated using VAS score.Results The three groups of patients were not significantly different in MAP and HR when entering the operating room.From T1 to T3,group A and group B were significantly lower than group C in MAP and HR(P 0.01).At T2 and T3,group A was significantly lower than group B in MAP and HR(P 0.05 or P 0.01).From T4 to T7 after surgery,group A was significantly lower than group C in VAS score at rest(P 0.05 or P 0.01).From T5 to T7,group A was significantly lower than group C in VAS score at activity(P 0.01).From T5 to T7 after surgery,group A was significantly lower than group B in VAS score at rest(P 0.05).At T6 and T7,group A was significantly lower than group B in VAS score at activity(P 0.05).Conclusion The application of parecoxib sodium pre-emptive analgesia in upper limb fracture surgery can reduce intraoperative vascular reactions and relieve patients' intraoperative and postoperative pain response and shows few side effects.