Expression of Survivin in colorectal cancer and correlation

Objective To study the relationship between Survivin(the new member of inhibition apoptosis protein family)expression and the biological behaviors of colorectal cancer,and the relationship between Survivin,P53,and Bcl-2 expression.Methods Immunohistochemical SP method was used to examine the single and joint expression of Survivin,P53 and Bcl-2 proteins.Results The positive rates of Survivin expression were 60% in cancer tissues and 0% in nomal tissues,respectively.The difference between the rates was significant(P0.01).Survivin expression had no significant relationship with patient sex,tumor location,Duke's stage and lymph node metastasis(P0.05),but had significant relationship with patient age and differentiation grade(P0.05);and P53 expression had significant relationship with Survivin expression(P0.005).The Bcl-2 expression had no significant relationship with Survivin expression(P0.9).Conclusion The over expression of Survivin in colorectal cancer may become a new tumor marker and prognosis factor.