Expression of survivin in colorectal cancer and correlation

Objective To study the relationship between survivin(the new member of inhibition apoptosis protein family)expression and the biological behaviors of colorectal cancer,the relationship between survivin expression and bcl-2 expression,ki-67 label index.Methods Immunohistochemical SP method was used to examine the single and joint expression of survivin,bcl-2 proteins,and the ki-67 label index in cancer tissue and marge tissue.Results(1)The positive rates of survivin expression were 63.6% in cancer tissue and 0% in marge tissue respectively.The difference between the rates was significant(P0.01).Survivin expression didn't have significant relationship with patient age,differentiation grade,tumor size,tumor location,Duke's stage and lymph node metastasis(P0.05),but had significant relationship with sex of colorectal cancer patients(P0.05).(2)The bcl-2 expression didn't have significant relationship with the survivin expression(P0.05).(3)The mean ki-67 label index in survivin positive tumors was significantly higher than that of survivin negative tumors(P0.01).Conclusion Survivin plays a certain role in the oncogenesis and progression of colorectal cancer by up-regulating cell proliferation;the over expression of survivin is an independent event in the colorectal cancer tumorigenesis.