Detection and Clinical Significance of Apolipoprotein AI and B in Patients with Liver Cirrhosis Complicated by Hepatic Encephalopathy

Objective To explore and analyze the clinical detection value of apolipoprotein AI and B in patients with liver cirrhosis complicate by hepatic encephalopathy. Methods The blood samples of 65 patients with liver cirrhosis in observation group(including 19 cases of complicated by hepatic encephalopathy) and 65 healthy individuals in control group were compared and analyzed. Results Serum apolipoprotein AI and B levels were both significantly lower than those of control group(P0.01).Serum apolipoprotein AI,B and albumin levels in those patients complicated by hepatic encephalopathy were significantly decreased(P0.05).Among 19 patients complicated by hepatic encephalopathy,serum apolipoprotein AI level in the patients with improved condition was increased significantly(P0.01),while that in the deteriorating patients was decreased significantly(P0.05).There was no statistically significant difference in serum level of apolipoprotein B between before and after the treatment. Conclusions Dynamic detection of serum apolipoprotein AI and B is conducive to predicting the prognosis of liver cirrhosis patients complicated by hepatic encephalopathy.Serum apolipoprotein AI and B detection combined with the clinical diagnosis could improve the targeted therapy so as to further enhance the therapeutic efficacy.