Clinical significance of S100B in serum from patients with cirrhosis complicated by hepatic encephalopathy

Objective:To investigate the clinical significance of S100B in serum from patients with cirrhosis complicated by hepatic encephalopathy.Methods:The serum levels of S100B from 35 healthy contols and 105 patients wih hepatic encephalopathy were measured by enzyme-linked immunosorbent assay(ELISA),and the liver function,electrolyte,and coagulation function determined.The data were analyzed with statistical methods.Results:1.The serum levels of S100B were markedly higher in patients with hepatic encephalopathy in those without hepatic encephalopathy,and there was a significant difference between the 2 groups(P0.01).After Sodium glutamate,Arginine,Mannitolor,Retention enema therapy,the serum levels of S100B in 29 patients with hepatic encephalopathy decreased significantly along with amelioration of hepatic encephalopathy.There was a significant difference between patients who before treatment and after treatment,The serum levels of S100B in 15 patients with hepatic encephalopathy complicated with hyponatremia were markedly higher than those with hepatic encephalopathy and hyponatremia only,and there was a significant difference among those.2.After correlation study on child-pugh classification and serum levels of S100B,the correlation coefficient of child-pugh classification and S100B is very high(r=0.898),It indicates child-pugh classification markedly positive correlated with serum levels of S100B.3.The freshpatients without hepatic encephalopathy are grouped by the serum levels of S100B,the incidence of turning into hepatic encephalopathy of the groups of higher serum levels of S100B is evidence higher than the incidence of the group of lower level.Conculsion:The serum levels of S100B are helpful to diagnose hepatic encephalopathy and estimate the severity of cerebral injury,and make for estimating the state of an illness and judging the evolving disease.