The curative effect of plasma exchange on patients with severe hepatitis

Objective To evaluate the curative effect of plasma exchange in the treatment of severe hepatitis by the model for end-stage liver disease. Method 62 patients with severe hepatitis were treated with plasma exchange. Blood chemical data were collected pre-treatment and post-treatment. All of the patients graded with MELD and the fatality rate were observed three months later. Results The concentration of TBil,TBA,ALT in the sera were much lower than post-treatment (P0.05);After plasma exchange treatment,overall death rate of 62 patients was 56.5%,much less than the prediction of mortality (76.3%,P0.05),especially in the group of patients with MELD score less than 30. Conclusion As a hepatic support device,plasma exchange is a useful way for therapy of severe hepatitis.