The expression of MCM7,CDK2 and p27 in papillary thyroid carcinoma and their significance

Purpose To explore the expression of MCM7,CDK2 and p27 in papillary thyroid carcinoma and the mechanisms involved in the carcinogenesis and development of papillary thyroid carcinoma.Methods Immunohistochemical SP method was used to detect the expression of MCM7,CDK2 and p27 protein in 40 cases of papillary thyroid carcinoma,30 cases of thyroid adenoma,30 cases of nodular goitre and 20 cases of normal thyroid gland tissue.Results The positive rates of MCM7 and CDK2 expressions in papillary thyroid carcinoma were 100.00%(40/40) and 80.00%(32/40).The expression of MCM7 and CDK2 protein in the papillary thyroid carcinoma group was significantly higher than that in the thyroid adenoma,nodular goitre and normal thyroid tissue groups(P0.01,P0.01).The positive rates of p27 expressions in papillary thyroid carcinoma were 22.50%(9/40).The expression of p27 protein in the papillary thyroid carcinoma group was significantly lower than that in the thyroid adenoma,nodular goitre and normal thyroid tissue groups(P0.01).A negative correlation was observed between the expressions of MCM7 and p27 protein in papillary thyroid carcinoma tissue(r=-0.334,P0.05).A negative correlation was observed between the expressions of CDK2 and p27 protein in papillary thyroid carcinoma tissue(r=-0.413,P0.01).A positive correlation was observed between the expressions of MCM7 and CDK2 protein in papillary thyroid carcinoma tissue(r=0.550,P0.01).Conclusions The high expression of MCM7 and CDK2 protein and low expression of p27 protein may be involved in and the carcinogenesis of papillary thyroid carcinoma.Combined detecting of MCM7,CDK2 and p27 protein may be used as a reference index in the early diaynoses and determine the biological indicators of cell proliferation of papillary thyroid carcinoma.