ScholarLens Back to search
2006•The Practical Journal of CancerRequires access

Studies the Biological Behavior of Ovarian Cancer Cell Line SKOV3 Silenced Her-2 by RNAi with Animal Experiment

Meimei Wang

Open publisher page 0 citations

Abstract

Objective To study the effect of gene silencing Her-2 on SKOV3/siRNA cells by animal experiment.Methods Cells of SKOV3/siRNA and SKOV3 were transplanted subcutaneously in NOD-SCID mice respectively,observed volume of the two tumor,killed mice after 3 monthes and weighed the tumor,RT-PCR was used to assess the effect of Silencing Her-2.Results tumorigenesis of SKOV3/siRNA cell lines in NOD-SCID mice decreased significantly.Conclusion Silencing of Her-2 by RNAi can inhibit tumorigenesis of ovarian cancer with animal experiment and may become a new approach of ovarian cancer therapy.

About this research paper

What this paper is about

Objective To study the effect of gene silencing Her-2 on SKOV3/siRNA cells by animal experiment.Methods Cells of SKOV3/siRNA and SKOV3 were transplanted subcutaneously in NOD-SCID mice respectively,observed volume of the two tumor,killed mice after 3 monthes and weighed the tumor,RT-PCR was used to assess the effect of Silencing Her-2.Results tumorigenesis of SKOV3/siRNA cell lines in NOD-SCID mice decreased significantly.Conclusion Silencing of Her-2 by RNAi can inhibit tumorigenesis of ovarian cancer with animal experiment and may become a new approach of ovarian cancer therapy.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the effect of gene silencing Her-2 on SKOV3/siRNA cells by animal experiment.Methods Cells of SKOV3/siRNA and SKOV3 were transplanted subcutaneously in NOD-SCID mice respectively,observed volume of the two tumor,killed mice after 3 monthes and weighed the tumor,RT-PCR was used to assess the effect of Silencing Her-2.Results tumorigenesis of SKOV3/siRNA cell lines in NOD-SCID mice decreased significantly.Conclusion Silencing of Her-2 by RNAi can inhibit tumorigenesis of ovarian cancer with animal experiment and may become a new approach of ovarian cancer therapy.

Key concepts: Gene silencing, RNA interference, Carcinogenesis, Ovarian cancer, Cancer research, Biology, Nod, Cell

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Studies the Biological Behavior of Ovarian Cancer Cell Line SKOV3 Silenced Her-2 by RNAi with Animal Experiment — Research Paper | ScholarLens