Clinical distribution of Escherichia coli infection and its drug resistance

Objective To investigate clinical distribution of Escherichia coli isolation and its drug resistance in our hospital from 2006 to 2010 and provide evidence for the rational clinical drug use and reduction of ESBLs producing.Methods Retrospective survey was carried out on the clinical distribution of the Escherichia coli strains isolated during this period and drug susceptibility test was conducted by using VITEK-60 automatic microbio analyzer and K-B agar diffusion method.Results Totally 657 strains of Escherichia coli were isolated during this period,312 strains were isolated from urine samples,accounting for 47.5%.The strains were mainly isolated in ICU and surgical wards,accounting for 60%.The isolation rate of ESBLs-positive Escherichia coli increased from 54.5% in 2006 to 70.7% in 2010(P0.05).The resistance rates of Escherichia coli to commonly used antibiotics were in upward trend,especially for the 3rd and 4th generation cephalosporin.The drug resistance rates of ESBLs-positive strains to 11 antibiotics,including ampicillin,cefazolin and ceftriaxone,were higher than ESBLs-negative strains.Conclusion Escherichia coli infection is more serious than before,the multi drug resistance rates to commonly used antibiotics is in increase,and the detection rate of ESBLs producing Escherichia coli is also in increase.It is necessary to strengthen the clinical surveillance of the pathogens.