Clinical distribution and surveillance of bacterial resistance of 1 526 strains of escherichia coli

Objective To provide references for control and therapy of infection by analyzing the distribution and drug resistance of escherichia coli in five consecutive years. Methods escherichia coli was collected in our hospital from 2008 to 2012. Antimicrobial susceptibility test was conducted by Kirby-Bauer method. The data were analyzed by WHONET 5. 6. Results In five years,1526 strains of escherichia coli were isolated,the majority of which were isolated from the specimen of urine( 33. 6%). The bacteria was mainly distributed in general surgery( 24. 2%),urology( 17. 2%) and emergency department( 13. 8%). The positive rate of ESBLs was 51. 8%. The ESBLs-producing strains to most of the drugs were significantly more resistant than the corresponding non-ESBLs-producing strains( P 0. 01). The carbapenem-resistant escherichia coli( 0. 2%,3 /1526) were identified. Conclusions escherichia coli presents various degrees of resistance to antimicrobial agents. Carbapenems remains to have the highest activity against escherichia coli, but carbapenem-resistant escherichia coli has appeared. It is necessary to strengthen the surveillance to prevent the spread of the drug resistance.