Overexpression of osteopontin and CD44v6 in the non-small cell lung cancer

Objective:To explore the expression and role of osteopontin(OPN) and CD44v6 in the non-small cell lung cancer and analyze the relationship between its expression and clinicopathologic features.Methods:The expression of OPN and CD44v6 was studied by immunohistochemistry in 56 cases of non-small cell lung carcinoma tissues.Results:In 56 cases of non-small cell lung carcinoma tissues,the expression rates of OPN and CD44v6 were 71.4%,67.8%,respectively.There was a strong correlation between the expression of OPN and CD44v6 in non-small cell lung cancer,it was obviously related with tumor degree of lymphatic vessel invasion or long distant lymph node metastases(P0.05).Conclusion:OPN and CD44v6 may play an important role in the progression of non-small cell lung carcinomas and they may involve in the invasion and metastasis of non-small cell lung carcinomas.