The Clinical Efficacy of LEEP for Cervical Intraepithelial Neoplasia and the Value of High Risk HPV in the Postoperative Follow-up

Objective To study the clinical efficacy of loop electrosurgical excision procedure(LEEP) for cervical intraepithelial neoplasia(CIN) and the value of high risk human papilloma virus(HR HPV) in postoperative follow-up.Methods 120 cases of cervical intraepithelial neoplasia(CIN) patients were given the treatment of loop electrosurgical excision procedure(LEEP) and cervical cold knife conization(CKC) respectively,the surgery and complications of 2 groups were observed and compared.During the follow-up,HR-HPV were used to check and evaluate its value in the detection of residue and recurrence preoperation and 6 monthly after operation.Results The recovery rate of patients in observation group was 96.7%,while that of control group was 93.3%,there was no statistical difference(P0.05);the average operation time of patients in observation group was(7.4+1.6) min,the blood loss intraoperation was(8.1+3.4) ml,the incision healing time was(28.2+3.3) days,which were better than those of the control group;the postoperative bleeding off scabs of patients in observation group was greater than the incidence of menstrual quantity,it was 3.3%,which was far below than that of 13.3% in the control group(P0.05).The total HR-HPV positive rate of 120 patients preoperation was 78.3%(94/120),the HR-HPV total positive rate 6 months after the operation was 16.3%,(26/120).The lesions persist rate and the recurrence rate of positive HR-HPV group after LEEP were significantly higher than those of negative group(P0.05),the sensitivity of HR HPV detection of lesions persist or recurrence was 100%,the specific degree was 88.3%,the positive predictive value(PPV) was 42.1% and the negative predictive value(NPV) was 100%.Conclusion The curative rate of LEEP for CIN is a safe and effective method,and it is worthy of clinical promotion.Postoperative follow-up of high-risk HPV has an important role in predicting development and recurrence of lesions.