Clinical study on loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia with high-risk human papilloma virus( HR-HPV) infection

Objective To study the clinical effects of loop electrosurgical excision procedure( LEEP) in cervical intraepithelial neoplasia( CIN) patients with high-risk human papilloma virus( HR-HPV) infection. Methods Ninety-eight CIN patients with HR-HPV infection were treated with LEEP. All patients were performed with HR-HPV test both before and after LEEP. Clinical effects of the patients were assessed. Results All patients were successfully operated. The cure rate was 90. 8%( 89 /98),and the recurrence rate was 9. 2%( 9 /98) after 1-year follow-up. The cure rate in patients with CIN Ⅰ was 100%( 64 /64), significantly higher than 73. 5%( 25 /34) in patients with CINⅡ- Ⅲ( P 0. 01),and the recurrence rate of patients with CIN Ⅰ was significantly lower than that of patients with CIN Ⅱ- Ⅲ( 0% versus 26. 5%, P 0. 01). Positive rate of HR-HPV was 31. 6%( 31 /98) 6 months after the treatment,significantly lower than that before LEEP( P 0. 01),and negative conversion rate was 68. 4%( 67 /98); and 1 year later,they continued to decrease to 15. 3%( 15 /98) and 84. 7%( 83 /98),respectively,all with statistical significance( P 0. 01). Conclusion LEEP is effective in the treatment of CIN,also it can eliminate most of the HR-HPV infections,thus reduce the recurrence rate of CIN and incidence of cervical cancer. In addition,it' s easy to operate,with fewer complications,and worthy of promotion.