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2010•Unpublished venueRequires access

The Effects of SBYHF on Proliferation and Expression of COL-IV and CTGF in Rat Glomerular Mesangial Cells

Sisi Shao

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Abstract

Objective:To explore the molecular and cellular mechanism of SBYHF in ameliorating renal fibrosis through observing the effect of proliferation and expression of COL-IV and CTGF in Rat Glomerular Mesangial Cells.Methods:The proliferation of Rat GMC fostered in SBYHF was detected by CCK-8,the COL-IV secretion was detected by ELISA,and the CTGF was detected by Real Time PCR. Results:SBYHF significantly inhibited GMC proliferation(P0.01) and decreased the expression of COL-IV and CTGF (P0.01). Conclusion:SBYHF may through reduces the COL-IV secretion and down-regulated the expression of CTGF to inhibit the proliferation of Rat Glomerular Mesangial Cells. This may be the mechanism of SBYHF in ameliorating renal fibrosis.

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What this paper is about

Objective:To explore the molecular and cellular mechanism of SBYHF in ameliorating renal fibrosis through observing the effect of proliferation and expression of COL-IV and CTGF in Rat Glomerular Mesangial Cells.Methods:The proliferation of Rat GMC fostered in SBYHF was detected by CCK-8,the COL-IV secretion was detected by ELISA,and the CTGF was detected by Real Time PCR. Results:SBYHF significantly inhibited GMC proliferation(P0.01) and decreased the expression of COL-IV and CTGF (P0.01). Conclusion:SBYHF may through reduces the COL-IV secretion and down-regulated the expression of CTGF to inhibit the proliferation of Rat Glomerular Mesangial Cells. This may be the mechanism of SBYHF in ameliorating renal fibrosis.

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Available abstract

Objective:To explore the molecular and cellular mechanism of SBYHF in ameliorating renal fibrosis through observing the effect of proliferation and expression of COL-IV and CTGF in Rat Glomerular Mesangial Cells.Methods:The proliferation of Rat GMC fostered in SBYHF was detected by CCK-8,the COL-IV secretion was detected by ELISA,and the CTGF was detected by Real Time PCR. Results:SBYHF significantly inhibited GMC proliferation(P0.01) and decreased the expression of COL-IV and CTGF (P0.01). Conclusion:SBYHF may through reduces the COL-IV secretion and down-regulated the expression of CTGF to inhibit the proliferation of Rat Glomerular Mesangial Cells. This may be the mechanism of SBYHF in ameliorating renal fibrosis.

Key concepts: CTGF, Secretion, Mesangial cell, Endocrinology, Internal medicine, Fibrosis, Chemistry, Growth factor

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The Effects of SBYHF on Proliferation and Expression of COL-IV and CTGF in Rat Glomerular Mesangial Cells — Research Paper | ScholarLens