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2010•Chinese Journal of Integrated Traditional and Western NephrologyRequires access

Effects of SBYHF on Proliferation and Expression of Fibronectin and Interleukin-6 in Rat Glomerular Mesangial Cells

Feixia Dong

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Abstract

Objective:To explore the molecular and cellular mechanism of SBYHF in ameliorating renal fibrosis through observing the effect of proliferation and expression of fibronectin and interleukin-6 in rat glomerular mesangial cells.Methods:The proliferation of rat GMC fostered in SBYHF was detected by CCK-8;the fibronectin(FN) secretion was detected by ELISA;and the Interleukin-6(IL-6) was detected by real time PCR.Results:SBYHF significantly inhibited GMC proliferation(P0.01) and decreased the expression of FN and IL-6(P0.01).Conclusion:SBYHF may reduce the FN secretion and down-regulate the expression of IL-6 to inhibit the proliferation of rat glomerular mesangial Cells.This may be the mechanism of SBYHF in ameliorating renal fibrosis.

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What this paper is about

Objective:To explore the molecular and cellular mechanism of SBYHF in ameliorating renal fibrosis through observing the effect of proliferation and expression of fibronectin and interleukin-6 in rat glomerular mesangial cells.Methods:The proliferation of rat GMC fostered in SBYHF was detected by CCK-8;the fibronectin(FN) secretion was detected by ELISA;and the Interleukin-6(IL-6) was detected by real time PCR.Results:SBYHF significantly inhibited GMC proliferation(P0.01) and decreased the expression of FN and IL-6(P0.01).Conclusion:SBYHF may reduce the FN secretion and down-regulate the expression of IL-6 to inhibit the proliferation of rat glomerular mesangial Cells.This may be the mechanism of SBYHF in ameliorating renal fibrosis.

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Available abstract

Objective:To explore the molecular and cellular mechanism of SBYHF in ameliorating renal fibrosis through observing the effect of proliferation and expression of fibronectin and interleukin-6 in rat glomerular mesangial cells.Methods:The proliferation of rat GMC fostered in SBYHF was detected by CCK-8;the fibronectin(FN) secretion was detected by ELISA;and the Interleukin-6(IL-6) was detected by real time PCR.Results:SBYHF significantly inhibited GMC proliferation(P0.01) and decreased the expression of FN and IL-6(P0.01).Conclusion:SBYHF may reduce the FN secretion and down-regulate the expression of IL-6 to inhibit the proliferation of rat glomerular mesangial Cells.This may be the mechanism of SBYHF in ameliorating renal fibrosis.

Key concepts: Fibronectin, Secretion, Internal medicine, Endocrinology, Mesangial cell, Interleukin, Chemistry, Kidney

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Effects of SBYHF on Proliferation and Expression of Fibronectin and Interleukin-6 in Rat Glomerular Mesangial Cells — Research Paper | ScholarLens