Clinical research of sequential mechanical ventilation in the treatment of severe pneumonia

Objective To investigate the effect of sequential mechanical ventilation in the treatment of severe pneumonia. Methods 50 patients with severe pneumonia were randomly divided into observation group and control group with 25 cases in each. The control group reduced ventilator parameters to weaning after the condition improved gradually. After the presence of pulmonary infection control window,extubating noninvasive ventilationto assisted respiratory therapy. Invasive mechanical ventilation time,total time of mechanical ventilation and ventilator associated pneumonia incidence,mortality and re- intubation conditions of the two groups were compared. Results The differences of the time out of the window,respiratory frequency,heart rate,systolic pressure,diastolic pressure,partial pressure of carbon dioxide contrast and oxygenation index window between the two groups were not statistically significant( P 0. 05). The differences of respiratory frequency of patients with noninvasive breathing and non- invasive ventilation after 2 hours of observation group,the heart rate,systolic and diastolic blood pressure,partial pressure of carbon dioxide and oxygen index contrast were not statistically significant( P 0. 05). Invasive ventilation time in observation group was( 6. 68 ± 1. 81) d,the total mechanical ventilation time was( 11. 08 ± 2. 92) d,ventilator related pneumonia occur rate was 4%,these were significantly less than the control group( all P 0. 05). Conclusions Sequential mechanical ventilation in the treatment of severe pneumonia can effectively shorten invasive mechanical ventilation time,reduce the incidence of ventilator associated pneumonia.