Study on the effect of burn deep II°wound healing on Wistar rats about Zhenshi burn ointment application

Objective To explore the mechanism of action to treat the burn wound by zhenshi burn ointment and to provide experimental evidence to guide the clinical treatment,which was based on the experimental observation of animal about Zhenshi burn ointment promoted wound healing.Methods 78 Wistar rats were randomly divided into model group(72rats) and normal control group(6rats).72 Wistar rats whose back being burned deep second degree were randomly divided into 3 groups.In group D,6 normal rats were selected.In group A,the right side of wounds were the experimental group,the left side of wounds were the control group.The wounds of experimental group were allocated for treatment with zhenshi burn ointment.The wounds of control group were treated with Vaseline pledget.In group B,all the wounds were allocated for treatment with zhenshi burn ointment.In group C,all the wounds were allocated for treatment with Vaseline pledget.To observe the wound healing of wound,the pathological changes,collagen changes and hydroxyproline content.Results Zhenshi group rats'wound healing rate at different time points of was higher than that of the control group(P 0.05),the healing time was shortened obviously(P 0.05),wound healing of epithelium degree was better than that of the control group,the collagen distribution was higher than that of the control group,Hydroxyproline content was significantly higher than that of the control group.Conclusion Zhenshi burn ointment significantly promoted wound healing and reduced the scar formation by stimulating the expression of hydroxyproline,regulating collagen synthesis and the growth of epithelial cells in the wound.