Comparative study on two kinds of sequential therapy and the 10-day standard triple therapy for Eradication of helicobacter pylori

Objective To evaluate the eradication rate of H.pylori with furazolidone based sequential therapy, tinidazole based sequential therapy and 10-day triple therapy. Methods 163 patients with H.pylori positive peptic ulcer disease or chronic gastritis were randomly divided into group A, B and C. Group A 54 cases received sequential therapy,Eesomeprazole 20 mg plus Amoxicillin 1.0 g for the first 5 days, followed by Esomeprazole 20 mg, Clarithromycin 500 mg and Furazolidone 100 mg for the next 5 days. Group B 55 cases received sequential therapy, Esomeprazole 20 mg and Amoxicillin 1.0 g for the first 5 days, followed by Esomeprazole 20 mg, Clarithromycin 500 mg and Tinidazole 500 mg for the remaining 5 days. Group C 54 cases received triple therapy, Esomeprazole 20 mg, Amoxicillin 1.0 g and Clarithromycin 500 mg for 10 days. All drugs were given twice daily. The adverse effects were recorded during the course of treatment eradication of H. pylori was determined by 14C-urea breath test 4 weeks after completion of treatment. Results Per-protocol analysis(PP) and intention-to-treat analysis (ITT)eradication rates were 92.0%,85.2% in group A, 77.6%,69.1% in group B, and 73.5%,66.7% in group C respectively. Eradication rates in group A were significantly higher than those in group B and group C(P0.05). No significantly difference was found between group B and group C(P 0.05). Conclusion Furazolidone based sequential therapy could achieve higher eradication rate of H.Pylori compared with tinidazole based sequential therapy and 10-day triple therapy, which can be used as first-line therapy at initial treatment.