Comparative study on two kinds of sequential therapy and the standard triple therapy in Helicobacter pylori infection treatment

Objective:To evaluate the eradication rate of H.pylori in furazolidone-based sequential therapy,tinidazole-based sequential therapy and 7-day triple regimen.Methods:Patients with pylori-positive peptic ulcer disease or chronic gastritis were randomly divided into group A,B and C.Group A received 10 days sequential therapy,i.e.,rabeprazole 10 mg plus amoxicillin 1 g for the first 5 days,followed by rabeprazole 10 mg,clarithromycin 500 mg and furazolidone 100 mg for the next 5 days.Group B received rabeprazole 10 mg and amoxicillin 1g for the first 5 days,followed by rabeprazole 10 mg,clarithromycin 500 mg and tinidazole 500 mg for the remaining 5 days.Group C received rabeprazole 10 mg,amoxicillin 1 g and clarithromycin 500 mg for 7 days.All drugs were given twice daily.The adverse effects were recorded during the course of treatment.Eradication of H.pylori was determined by 14C-urea breath test 4 weeks after completion of treatment.Results:Per protocol(PP)and intention-to-treat(ITT)eradication rates were respectively 91.43%,84.21% in Group A,77.78%,68.29% in Group B,and 72.50%,65.91%in Group C.Eradication rates in Group A were significantly higher than those in Group B and Group C(P0.05).No significantly difference was found between Group B and Group C(P0.05).Conclusion:Furazolidone-based sequential therapy could achieve higher eradication rate of H.Pylori compared with tinidazole-based sequential therapy and 7-day triple regimen,which can be used as first-line therapy.