Observation of the sequential rescue therapy regimen on eradicating Helicobacter pylori

Objective To compare the efficacy of sequential therapy and traditional quadruple therapy on eradicating Helicobacter pylori(H.pylori)infection after first line triple therapy failure.Methods Sixty-eight patients with H.pylori infection who failed first line triple therapy were randomly divided into two groups.Patients in therapeutic group received sequential therapy:esomeprazole(20 mg)and amoxicillin(1 000 mg)twice daily for the first 5 days,followed by esomeprazole(20 mg),clarithromycin(500 mg)and metronidazole(400 mg)twice daily for the next 5 days.Patients in control group received quadruple therapy:esomeprazole(20 mg),amoxicillin(1 000 mg),furazolidone(100 mg)and colloidal bismuth pectin(100 mg)twice daily for 7 days.H.pylori was detected by 14C-urea breath test at 4 weeks after treatment.Results The eradication rate of H.pylori in the sequential therapy group was 93.9%,and the eradication rate of H.pylori in the traditional quadruple therapy group was 73.3%.There was a significant difference between two groups(P0.05).Conclusion Sequential therapy has a higher eradication rate of H.pylori compared with the traditional quadruple therapy.It is an effective eradication therapy for people failed in previous H.pylori eradication management.