Effect of Pantoprazole in the Treatment of Peptic Ulcer

Objective:To evaluate the effect of pantoprazole in the treatment of peptic ulcer. Method:93 patients with active peptic ulcer confirmed by endoscopy were randomly allocated to study group(group A, n=50) and control group (group B, n=43). Pantoprazole was given a dose of 40 mg po at 8 am in group A, and group B received ranitidine 300 mg p.o. at bedtime for 4 weeks. Results:①The mean time of upper abdominal pain regression for group A (4.4 days) was markedly less than that for group B(7.6 days) and the healing rate of ulcer for group A(96.0%) was significantly higher than that for group B(69.8%) with statistical differences (P0.05,P0.01).②In group A and group B, the healing rates of duodenal ulcer were 96.9% and 71.4% respectively, and gastric ulcer were 94.4% and 66.7% respectively. There were significant differences (P0.01,P0.05). Conclusion:Our data show that the effect of pantoprazole in the treatment of peptic ulcer is satisfactory, and gains an advantage over that of ranitidine.