Clinical effect of Pantoprazole combined with Compound Bismuth and Magnesium Granules in the treatment of peptic ulcer

Objective To observe clinical effect of Pantoprazole combined with Compound Bismuth and Magnesium Granules in the treatment of peptic ulcer. Methods 90 patients with peptic ulcer in People′s Hospital of Inner Mongolia Autonomous Region from July 2014 to April 2015 were selected and divided into treatment group and control group according to the random number table method, each group of 45 cases. Treatment group was given Pantoprazole, Compound Bismuth and Magnesium Granules. Control group was given Pantoprazole, Aluminium Phosphate Gel. The patients with gastric ulcer or compound ulcer were treated with oral administration for 8 weeks, and patients with duodenal ulcer were treated with oral administration for 4 weeks. The ulcer healing under endoscope, remission of gastrointestinal symptoms after taking medicine for 2 weeks, ADR between two groups were observed. Results Total effective rate of ulcer healing was 97.8%(44/45), 91.1%(41/45) in treatment group and control group respectively, with no statistical difference(P 0.05). The ulcer healing rate was 88.9%(40/45), 71.1%(32/45) in treatment group and control group respectively, with statistical difference(P 0.05). Remission total effective rate of symptoms after tak-ing medicine for 2 weeks was 80.0%(36/45), 75.6%(34/45) in treatment group and control group respectively, with no statistical difference(P 0.05). Significant efficiency rate of symptoms after taking medicine for 2weeks was 40.0%(18/45), 0.0%(0/45) in treatment group and control group respectively, with statistical significantly difference(P 0.01). Incidence rate of ADR was 2.2%(1/45), 17.8%(8/45) in treatment group and control group respectively, with statistical difference(P 0.05). Conclusion Ulcer healing and early symptom improvement effect of Pantoprazole combined with Compound Bismuth and Magnesium Granules in the treatment of peptic ulcer are significantly better than that of Pantoprazole combined with Phosphate Aluminum Gel, and less adverse reaction, it is the first choice of clinical medicine, it is worthy of promotion and application.