Controlled Study on Efficacy Jieyu Pill and Venlafaxine in Treating the first onset Depression

Objective To investigate the clinical efficacy and the side-effects of Jieyu Pill(JYP)in treating the first onset depression.Methods The randomized controlled study was conducted in 22 patients in the treated group and 19 patients in the control group treated with venlafaxine(Ven).The efficacy of treatment was evaluated before treatment and 14,28,and 42 days after treatment,with Hamilton depression rating scale,self-made side effect scale and clinical global impression.Results JYP was effective in treating depression,the markedly effective rate being 68.18%,corresponded to that of Ven(73.68%).After treatment,the scores assessed by HAMD were all lower than those before treatment(P0.05)respectively,but comparision between the two groups showed insignificant difference(P0.05).However,the side effects of JYP was significantly lower than that of Ven(χ2=11.11,P0.01).Conclusion JYP in treating the first onset depression shows the efficacy corresponded to that of Ven and with less the sida-effects.