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2011•Medical Journal of Chinese People's HealthRequires access

Comparative study of Clozapine and Aripiprazole in zhe treatment of Schizophrenia

BI Wei-hong

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Abstract

Objective:To compare the efficacy and safety between Clozapine and Aripiprazole.Methods:60 patients with schizophrenia by CCMD-3 were randomly allocated to two groups treated with Clozapine or Aripiprazole for 6 weeks.The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Symptoms Scale(TESS) were used to evaluate efficacy and adverse effects.respectively before treatment and at zhe end of 2,4 and 6 weeks.Results: The efficacy rate of Aripiprazole was 93.33%,in which 86.67% were improved markedly.The efficacy rate of Clozapine was 90.00%,in which 83.33% were improved markedly.The PANSS scores in both groups decreased significantly after treatment;There was no significant difference in efficacy between two groups.Aripiprazole had fewer side effects zhan Clozapine.Conclusions: Aripiprazole is an effective drug for schizophrenia with few side effects.

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What this paper is about

Objective:To compare the efficacy and safety between Clozapine and Aripiprazole.Methods:60 patients with schizophrenia by CCMD-3 were randomly allocated to two groups treated with Clozapine or Aripiprazole for 6 weeks.The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Symptoms Scale(TESS) were used to evaluate efficacy and adverse effects.respectively before treatment and at zhe end of 2,4 and 6 weeks.Results: The efficacy rate of Aripiprazole was 93.33%,in which 86.67% were improved markedly.The efficacy rate of Clozapine was 90.00%,in which 83.33% were improved markedly.The PANSS scores in both groups decreased significantly after treatment;There was no significant difference in efficacy between two groups.Aripiprazole had fewer side effects zhan Clozapine.Conclusions: Aripiprazole is an effective drug for schizophrenia with few side effects.

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Available abstract

Objective:To compare the efficacy and safety between Clozapine and Aripiprazole.Methods:60 patients with schizophrenia by CCMD-3 were randomly allocated to two groups treated with Clozapine or Aripiprazole for 6 weeks.The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Symptoms Scale(TESS) were used to evaluate efficacy and adverse effects.respectively before treatment and at zhe end of 2,4 and 6 weeks.Results: The efficacy rate of Aripiprazole was 93.33%,in which 86.67% were improved markedly.The efficacy rate of Clozapine was 90.00%,in which 83.33% were improved markedly.The PANSS scores in both groups decreased significantly after treatment;There was no significant difference in efficacy between two groups.Aripiprazole had fewer side effects zhan Clozapine.Conclusions: Aripiprazole is an effective drug for schizophrenia with few side effects.

Key concepts: Aripiprazole, Clozapine, Schizophrenia (object-oriented programming), Positive and Negative Syndrome Scale, Adverse effect, Medicine, Internal medicine, Side effect (computer science)

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