Expression of p53、bcl-2、PCNA、ER、PR and their significance in primary breast cancer

Objective:To study the relationship between expression of p53 protein, bcl-2, the level of ER, PR in tissues of breast cancer and their pathological types, histological grades, prognosis.Methods:Samples of 57 breast cancer tissues were examined with the immunohistochemical staining(S-P) for expression of p53 protein and bcl-2、 PCNA、 the level of ER, PR.Results:The positive expression of bcl-2 in tissues of breast cancer had a close relationship with breast cancre stages, with the increasing of the positive expression of bcl-2, the histology satge of breast cancer decreased. The expression of p53 and PCNA had a relationship with clinical stages of breast cancer, that was with the increasing clinical and histologic stages of breast cancer, the expression rate was going up. The positive rate of ER, PR decreasde with the increasing clinical and histologic stages of breast cancer.Conclusion:The prognosis is good in patients with high expression of bcl-2 and ER and while the high expression of p53 and PCNA indicates a bad prognosis.